Dr Christopher Staples

Senior Lecturer in Biomedical Sciences (Cancer Biology)

c.staples@bangor.ac.uk

  • PhD: Regulation of MAP kinase phosphatases
    University of Dundee, 2006鈥�2010

Teaching Credits

MSE-3016 Pathophysiology (10 credits) - Module Organiser

MSE-2025 Molecular Biology and Biochemistry (10 credits)聽

MSE-3013 Third Year Research Project聽

MSE-4025 Dissertation

Teaching and Supervision Roles

Undergraduate project/dissertation supervision. Supervision of PhD, MSc and MRes students.

Other roles

College representative on Research Concordat Committee

External and internal viva voce examiner

Teaching and Scholarship Awards

PGCertHE Stage 1 (2017)

PGCertHE Stage 2 (2018)

Fellow of the Higher Education Academy (HEA)

Work in the Staples laboratory focuses largely on the characterisation of novel genome stability factors. Genome instability and DNA damage are central pathogenic mechanisms involved in cancer predisposition, premature ageing and neurodegeneration. Indeed, some cancer therapies target cancer-specific defects in DNA repair or replication fork protection mechanisms, and as such a complete understanding of such mechanisms is a major asset in the fight against cancer.

We have identified several novel DNA repair and replication fork protection factors, and our aim is to gain mechanistic insight into the function of these largely unstudied proteins with the ultimate goal of using this knowledge to design novel cancer therapies and/or predict therapeutic response.

Investigation of novel replication fork protection factors Investigation of small-molecule inhibitors of the DNA damage response

2023

  • Published
    Crozier, L., Foy, R., adib, R., Kar, A., Holt, J., Pareri, A., Valverde, J., Riviera, R., Weston, W., Wilson, R., Regnault, C., Whitfield, P., Badonyi, M., Bennett, L., Vernon, E., Gamble, A., Marsh, J., Staples, C., Saurin, A. & Barr, A. & 1 others, Ly, T., 16 Nov 2023, In: Molecular Cell. 83, 22, p. 4062-4077 15 p.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review
  • Published
    Elgar, C. E., Yusoh, N. A., Tiley, P. R., Kolozsv谩ri, N., Bennett, L., Gamble, A., P茅an, E. V., Davies, M. L., Staples, C., Ahmad, H. & Gill, M. R., 18 Jan 2023, In: Journal of the American Chemical Society. 145, 2, p. 1236-1246 11 p.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review

2020

  • Published
    Bennett, L., Wilkie, A., Antonopoulou, E., Ceppi, I., Sanchez, A., Vernon, E., Gamble, A., Myers, K. N., Collis, S. J., Cejka, P. & Staples, C., 10 Jul 2020, In: Science Advances. 6, 28, 10 p., eaba5974.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review

2017

  • Published
    Williams, D. T. & Staples, C., 25 Aug 2017, Personalised Medicine. El-Khamisy, S. (ed.). Springer, Vol. 1007. p. 1-16 16 p. (Advances in Experimental Medicine and Biology).
    Research output: Chapter in Book/Report/Conference proceeding 鈥� Chapter

2016

  • Published
    Barone, G., Staples, C. J., Ganesh, A., Patterson, K. W., Bryne, D. P., Myers, K. N., Patil, A. A., Eyers, C. E., Maslen, S., Skehel, J. M., Eyers, P. A. & Collis, S. J., 14 Oct 2016, In: Nucleic Acids Research. 44, 18, p. 8772-8785 14 p.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review
  • Published
    Staples, C. J., Barone, G., Myers, K. N., Ganesh, A., Gibbs-Seymour, I., Patil, A. A., Beveridge, R. D., Daye, C., Beniston, R., Maslen, S., Ahel, I., Skehel, J. M. & Collis, S. J., 6 Sept 2016, In: Cell. 16, 10, p. 2565-75 11 p.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review
  • Published
    Myers, K. N., Barone, G., Ganesh, A., Staples, C. J., Howard, A. E., Beveridge, R. D., Maslen, S., Skehel, J. M. & Collis, S. J., 14 Oct 2016, In: Scientific Reports. 6, p. 35548
    Research output: Contribution to journal 鈥� Article 鈥� peer-review

2014

  • Published
    Staples, C. J., Myers, K. N., Beveridge, R. D., Patil, A. A., Howard, A. E., Barone, G., Lee, A. J., Swanton, C., Howell, M., Maslen, S., Skehel, J. M., Boutlon, S. J. & Collis, S. J., 1 Jul 2014, In: Journal of Cell Science. 127, p. 2910-2919
    Research output: Contribution to journal 鈥� Article 鈥� peer-review
  • Published
    Beveridge, R. D., Staples, C. J., Patil, A. A., Myers, K. N., Maslen, S., Skehel, J. M., Boulton, S. J. & Collis, S. J., 29 Oct 2014, In: Cell Cycle. 13, 21, p. 3450-3459
    Research output: Contribution to journal 鈥� Article 鈥� peer-review

2011

  • Published
    Dickinson, R. J., Delavaine, L., Cejudo-Mar铆n, R., Stewart, G., Staples, C. J., Didmon, M. P., Trinidad, A. G., Alonso, A., Pulido, R. & Keyse, S. M., 4 Nov 2011, In: Journal of Biological Chemistry. 286, 44, p. 38018-26 9 p.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review

2010

  • Published
    Staples, C. J., Owens, D. M., Maier, J. V., Cato, A. C. B. & Keyse, S. M., 20 Aug 2010, In: Journal of Biological Chemistry. 285, 34, p. 25928-40 13 p.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review

2009

  • Published
    Kucharska, A., Rushworth, L. K., Staples, C., Morrice, N. A. & Keyse, S. M., Dec 2009, In: Cellular Signalling. 21, 12, p. 1794-805 12 p.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review

2008

  • Published
    Ekerot, M., Stavridis, M. P., Delavaine, L., Mitchell, M. P., Staples, C., Owens, D. M., Keenan, I. D., Dickinson, R. J., Storey, K. G. & Keyse, S. M., 1 Jun 2008, In: Biochemical Journal. 412, 2, p. 287-98 12 p.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review

2007

  • Published
    Graham, D. A., Staples, C., Wilson, C. J., Jewhurst, H., Cherry, K., Gordon, A. & Rowley, H. M., Sept 2007, In: Journal of Fish Biology. 30, 9, p. 533-43 11 p.
    Research output: Contribution to journal 鈥� Article 鈥� peer-review

2022

  • There is an urgent requirement to identify specific, precision medicine drug targets that selectively kill PDACs with mutations in BRCA2 and other DNA repair factors, or which sensitise them further to existing treatments. We are therefore applying for funding to develop CRISPR-Cas9 dropout screening at Bangor 鈥揳 powerful technique for identifying novel precision medicine drug targets in cancer cells. While our initial focus is on PDAC, once in place this methodology can be applied to drive the discovery of drug targets for a wide array of human diseases.

    Funding awarded through the 91精品黑料吃瓜 Innovation and Impact Award (Research Wales Innovation Funding). Value = 拢49,466

    1 Apr 2022 鈥� 31 Mar 2023

    Activity: Other (Contributor)

2021

  • 20 Jun 2021

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)

  • Invited talk at the 26th UK Cilia Network Symposium

    17 May 2021

    Activity: Oral presentation (Speaker)

  • Member of scientific panel

    9 May 2021 鈫�

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)

  • 9 May 2021

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)

2020

  • Peer reviewer

    7 Nov 2020

    Activity: Publication peer-review (Editorial board member)

  • Peer-reviewer for UKRI Future Leaders Fellowships

    25 Oct 2020

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)

  • Peer review

    11 Sep 2020

    Activity: Publication peer-review (Editorial board member)

  • Reviewed a BBSRC Responsive Mode Application

    31 Aug 2020

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)

  • 21 Apr 2020

    Activity: Examination (Examiner)

  • 2 Apr 2020

    Activity: Examination (Examiner)

  • Provided peer review for a BBSRC project grant application

    4 Mar 2020

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)

  • Acted as peer reviewer

    7 Jan 2020

    Activity: Publication peer-review (Editorial board member)

2019

  • Supervised by Nikki Copeland

    13 Jun 2019

    Activity: Examination (Examiner)

  • External examiner

    4 Jun 2019

    Activity: Examination (Examiner)

  • 15 min talk at international conference

    2019

    Activity: Oral presentation (Speaker)

2018

  • Invited speaker to research seminar series

    18 Mar 2018

    Activity: Oral presentation (Speaker)

  • 29 Jan 2018

    Activity: Examination (Examiner)

2017

  • 9 Nov 2017

    Activity: Examination (Examiner)

  • Invited speaker to research seminar series

    11 May 2017

    Activity: Oral presentation (Speaker)

  • 01/07/2024 鈥� 15/07/2027 (Active)

  • 03/06/2024 鈥� 30/06/2026 (Active)

  • 01/01/2024 鈥� 15/01/2026 (Active)

  • 01/12/2023 鈥� 15/12/2026 (Active)

  • 01/10/2023 鈥� 30/11/2026 (Active)

  • 01/04/2023 鈥� 15/04/2025 (Finished)

  • 01/10/2022 鈥� 31/12/2025 (Active)

  • 01/10/2022 鈥� 31/03/2024 (Finished)

  • 01/07/2022 鈥� 31/03/2024 (Finished)

  • 01/05/2021 鈥� 31/08/2021 (Finished)

  • 01/01/2021 鈥� 31/03/2024 (Finished)

  • 01/02/2020 鈥� 29/02/2024 (Finished)

  • 01/12/2019 鈥� 31/12/2023 (Finished)

  • 01/07/2019 鈥� 01/08/2022 (Finished)

  • 01/06/2019 鈥� 01/08/2019 (Finished)

  • 01/01/2019 鈥� 30/06/2022 (Finished)

  • 01/05/2018 鈥� 31/07/2023 (Finished)

  • 01/11/2016 鈥� 31/08/2020 (Finished)

  • 01/10/2016 鈥� 31/07/2018 (Finished)

  • 01/10/2016 鈥� 19/08/2023 (Finished)