Miss Non Davies
Ardudwy
Normal Site
91精品黑料吃瓜
Holyhead Road
Bangor
Wales
LL57 2PZ
email: nnd22ppy@bangor.ac.uk
Rhagolwg
Non is a PhD student based at The Centre for Health Economics and Medicines Evaluation (CHEME). After obtaining a BSc Biomedical Sciences degree from The University of Manchester, she undertook a KESS2-funded MScRes degree at 91精品黑料吃瓜 in collaboration with Aparito - a wholly owned subsidiary of Eli Lilly and Company, with her thesis titled 鈥楧igital Health Solutions for Medication Adherence Support.鈥� Her PhD research focuses on medication adherence, under the primary supervision of Professor Dyfrig Hughes, funded by The Medical Research Council Trials Methodology Research Partnership Doctoral Training Program (MRC TMRP DTP).
Cymwysterau
- MSc: (MScRes) Clinical Sciences, Digital Health Solutions for Medication Adherence Support
91精品黑料吃瓜, 2024 - BSc: Biomedical Sciences
University of Manchester, 2022
Cyhoeddiadau
2024
- Cyhoeddwyd
Hassan, A. & Davies, N., 21 Maw 2024, Yn: Patient Preference and Adherence. 18, t. 721-731 11 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid
Gweithgareddau
2024
Aim
Trial run-in phases are sometimes used to select adherent patients, but the methods employed lack clear regulatory guidance and there are concerns about the transparency of reporting. This review aims to characterise the methods utilized for adherence measurement and reporting in run-in studies.
Methods
Clinicaltrials.gov using was searched using the terms "run*in" OR "lead*in" OR "enrichment鈥� OR 鈥渟ingle-blind placebo.鈥� Studies were included if they were phase 2 or 3 interventional studies with published results, containing the protocol and statistical analysis plan. The study start date (first patient enrolled) was restricted to 01/01/2010 to 04/03/2024. The Risk of Bias tool for Observational Adherence Studies (RoBOAS) and the ESPACOMP medication adherence reporting guidelines (EMERGE) were used to assess methodological and reporting quality.
Results
249 studies were identified, 34 were included for the analysis, of which 8 specified adherence to be the main purpose of the run-in. Run-ins were generally of poor methodological and reporting quality, with most using pill counts to measure adherence over 2 weeks, and only 23/34 having complete reporting of the adherence measurement, metric, and method of data aggregation. No studies reported the adherence phase studied.
Discussion and conclusion
Our review suggests that medication adherence is poorly reported in the run-in phase of drug trials, with the methods prone to bias. The findings support the need to develop guidelines on the reporting of medication adherence during the run-in phase, and should serve to inform future trial design, conduct and reporting, as well as have regulatory implications.
21 Tach 2024
Gweithgaredd: Cyflwyniad llafar (Siaradwr)1 Hyd 2024
Gweithgaredd: Cyflwyniad llafar (Siaradwr)
2023
1 Rhag 2023
Gweithgaredd: Cyflwyniad llafar (Siaradwr)As part of 91精品黑料吃瓜鈥檚 Community Day, researchers from CHEME engaged the public in an interactive exploration of health economics. Visitors of all ages participated in activities designed to highlight key economic concepts, such as resource allocation, cost-effectiveness, and healthcare prioritisation. Through hands-on exercises and discussions, attendees gained insights into the challenges of balancing NHS costs and patient needs.
14 Hyd 2023
Cysylltau:
Gweithgaredd: Mathau o waith ymgysylltu 芒'r cyhoedd a gwaith maes - G诺yl/Arddangosfa (Cyfrannwr)Public engagement in health economics took place at the Science Village during the 2023 National Eisteddfod in Wales, where staff and students of CHEME hosted an interactive stall engaging visitors of all ages. Activities included a card game exploring NHS costs and a creative exercise on measuring health and comparing healthcare interventions. These activities introduced key economic concepts such as opportunity cost and cost-effectiveness while gathering public insights. Designed and delivered by researchers with varying Welsh language proficiency, the sessions attracted up to 150 participants per day, enhancing public engagement with health economics.
8 Awst 2023 鈥� 9 Awst 2023
Cysylltau: